The structure of Klebsiella serotype 11 capsular polysaccharide |
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Authors: | Horst Thurow Yuen-Min Choy Norbert Frank Hiener Niemann Stephan Stirm |
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Affiliation: | Max Planck-Instiut fu¨r Immunbiologie, and Institut fu¨r Makromolekulare Chemie der Universita´t, Freiburg Germany |
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Abstract: | Using periodate oxidation, methylation analysis, the characterization of oligosaccharides obtained by partial acid hydrolysis, p.m.r. spectroscopy, and analytical ultracentrifugation, the structure of the (mildly alkali-treated) Klebsiella serotype 11 capsular polysaccharide has been elucidated. The tetrasaccharide repeating-unit comprises the sequence ?3)-β-D-Glcp-(1?3)-β-D-GlcUAp-(1?3)-α-D-Galp-(1→ with a 4,6-O-(1-car?yethylidene)-α-D-galactosyl residue linked to O-4 of the glucuronic acid residue. The structural basis for some serological cross-reactions of the Klebsiella K11 antigen is discussed, and it is shown that rabbit antisera against the Klebsiella K11 test-strain predominantly contain K agglutinins specific for branch-terminal 4,6-O-(1-car?yethylidene)-D-galactose. |
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Keywords: | To whom inquiries should be addressed. |
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