The Responses of Neurons of the Somatosensory Cortex to Stimulation of the Posterior Thalamus (PO) in WAG/Rij Rats Genetically Predisposed to Absence Epilepsy |
| |
| Authors: | D. A. Tsvetaeva E. Yu. Sitnikova V. V. Raevsky |
| |
| Affiliation: | 1.Institute of Higher Nervous Activity and Neurophysiology,Russian Academy of Sciences,Moscow,Russia;2.Pirogov Russian National Research Medical University,Ministry of Healthcare of the Russian Federation,Moscow,Russia |
| |
| Abstract: | In genetically predisposed WAG/Rij rats and healthy Wistar rats, we studied functioning of the paralemniscal region of the thalamo-cortical system. The responses of neurons of the somatosensory cortex to single electrical stimulation of the posterior nucleus of the thalamus were recorded in two- to three-monthold rats within the period when the epileptic activity was not developed. We revealed lower number of shortterm inhibitory responses in WAG/Rij rats as compared to Wistar rats. This may create preconditions for the spreading of spike-wave activity in the somatosensory cortex, which is an electrophysiological sign of absence epilepsy. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
