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A cytosine . cytosine base paired parallel DNA double helix with thymine . thymine bulges |
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| Authors: | M H Sarma G Gupta R H Sarma |
| Abstract: | 500 MHz 1H NMR studies using 2D-NOESY indicate that the oligonucleotide d(CTCTCT) at low pH forms a parallel double helix with cytosine . cytosine base pairs and thymine . thymine bulges. This unusual structure may explain the hypersensitivity of S1 nuclease at low pH towards supercoiled plasmids containing d(CT)n inserts. |
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