| 脂肪干细胞治疗心肌梗死的机制与新策略 |
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| 引用本文： | 汪晓强,;杨向群.脂肪干细胞治疗心肌梗死的机制与新策略[J].中华细胞与干细胞杂志(电子版),2014(3):50-55. |
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| 作者姓名： | 汪晓强 ;杨向群 |
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| 作者单位： | [1]第二军医大学学员旅学员12队,上海200433; [2]第二军医大学再生医学研究中心,上海200433; |
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| 基金项目： | 国家自然科学基金资助项目（31170934）; 第二军医大学大学生创新基金（ZD2013015） |
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| 摘 要： | 介绍脂肪干细胞（ADSCs）治疗心肌梗死机制及用于提高心肌梗死治疗效果的新策略。广泛查阅近年关于ADSCs用于治疗心肌梗死的基础与临床实验研究文献,并进行整理、综合与分析。ADSCs移植治疗心肌梗死的机制研究取得了一定的进展,其机制主要包括分化为心肌细胞、参与梗死区血管形成、通过旁分泌功能改善梗死区微环境等。对ADSCs进行缺氧耐受预处理、使用新型生物材料、联合细胞因子以及药物等,可以大大提高移植细胞的存活率,促进细胞的增殖与分化,改善心肌梗死治疗效果,加快心脏功能的恢复。ADSCs可能通过多种机制发挥治疗心肌梗死的作用,进一步提高移植细胞成活率和性能稳定性是增加ADSCs治疗心肌梗死效果的关键。随着研究的不断深入,ADSCs可能为未来心肌梗死的临床治疗带来新的希望。
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| 关 键 词： | 脂肪类 干细胞 心肌梗死 细胞移植 再生医学 |
Adipose-derived stem cells for treatment of myocardial infarction and new strategies |
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| Institution: | Wang Xiaoqiang, Yang Xiangqun.(Graduate School, Second Military Medical University, Shanghai 200433, China) |
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| Abstract: | Adipose-derived stem cell （ADSC） therapy for myocardial infarction has achieved great progress. The underlying mechanisms are multiplex, such as differentiating to myocardium and repairing the vascellum in infarction area by secretion of growth factors. Preconditioning of hypoxia-tolerance, combining with new biomaterials, cytokines or special agents for ADSCs not only increase the survival rate of transplanted-cells, but also promote cells to proliferate and differentiate. Thus the recovery of cardiac function is accelerated. ADSCs may play an important role in the treatment of MI by multiple mechanisms. Further increasing the survival rate of transplanted-cells and promoting their function will be the key point for improving the treatment effectiveness. With the progress of study, ADSCs may provide a new promising treatment of MI in the future. |
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| Keywords: | Fats Stem cells Myocardial infarction Cell transplantation Regenerative medicine |
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