Cell surface activation of progelatinase A (proMMP—2) and cell migration |
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引用本文: | NAGASEHIDEAKI. Cell surface activation of progelatinase A (proMMP—2) and cell migration[J]. Cell research, 1998, 8(3): 179-186 |
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作者姓名: | NAGASEHIDEAKI |
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作者单位: | DepartmentofBiochemistryandMolecularBiology,UniversityofKansasMedicalCenter,3901RainbowBlvd,KansasCit |
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摘 要: | Gelatinase A (MMP-2) is considered to play a critical role in cell migration and invasion.The proteinase is cerceted from the cell as an inactive zymogen.In vivo it is postulated that activation of progelationase A (proMMP-2) takes place on the cell surface mediated by membrane-type matrix metalloproteinases (MT-MMPs).Recent studies have demonstrated that proMMP-2 is recruited to the cell surface by interacting with tissue inhibitor of metalloproteinases-2 (TIMP-2) bound to MT1-MMP by forming a ternary complex.Free MT1-MMP closely located to the ternary complex then activates proMMP-2 on the cell surface.MT1-MMP is found in cultured invasive cancer cells at the invadopodia.The MT-MMP/TIMP-2/MMP-2 system thus provides localized expression of proteolysis of the extracellular matrix required for cell migration.
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关 键 词: | 胞外基质 明胶酶原 细胞表面活化 细胞迁移 |
Cell surface activation of progelatinase A (proMMP-2) and cell migration |
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Abstract: | Gelatinase A (MMP-2) is considered to play a critical role in cell migration and invasion. The proteinase is secreted from the cell as an inactive zymogen. In vivo it is postulated that activation of progelationase A (proMMP-2) takes place on the cell surface mediated by membrane-type matrix metalloproteinases (MT-MMPs). Recent studies have demonstrated that proMMP-2 is recruited to the cell surface by interacting with tissue inhibitor of metalloproteinases-2 (TIMP-2) bound to MT1MMP by forming a ternary complex. bee MT1-MMP closely located to the ternary complex then activates proMMP-2 on the cell surface. MT1-MMP is found in cultured invasive cancer cells at the invadopodia. The MTMMP/TIMP-2/ MMP- 2 system t bus provides localized expression of proteolysis of the extracellular matrix required for cell migration. |
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Keywords: | GelatinaseA MT-MMPs Cell surface activation TIMP-2 Extracellular matrix |
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