Advances in understanding bone cancer pain |
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Authors: | Goblirsch M J Zwolak P Clohisy D R |
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Institution: | University of Minnesota, Minneapolis, Minnesota, USA. |
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Abstract: | Experimental animal models of bone cancer pain have emerged and findings have provided a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key contributors to the generation and maintenance of bone cancer pain are tumor-induced osteolysis, tumor itself, and production of nociceptive mediators in the bone-tumor microenvironment. |
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Keywords: | bone cancer experimental model neurochemical markers osteolysis pain |
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