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Advances in understanding bone cancer pain
Authors:Goblirsch M J  Zwolak P  Clohisy D R
Institution:University of Minnesota, Minneapolis, Minnesota, USA.
Abstract:Experimental animal models of bone cancer pain have emerged and findings have provided a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key contributors to the generation and maintenance of bone cancer pain are tumor-induced osteolysis, tumor itself, and production of nociceptive mediators in the bone-tumor microenvironment.
Keywords:bone cancer  experimental model  neurochemical markers  osteolysis  pain
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