|
|||||
|
|
Effects of beauvericin to mammalian tissue and its production by Austrian isolates ofFusarium proliferatum and Fusarium subglutinans |
|
| Authors: | R. Krska R. Schuhmacher M. Grasserbauer M. Lemmens R. Lemmens-Gruber A. Adler H. Lew |
| Affiliation: | 1. Institute for Agrobiotechnology (IFA), Center for Analytical Chemistry and Laboratory of Plant Production Biotechnology, Konrad Lorenz Str. 20, A-3430, Tulln, Austria 2. Institute of Pharmacology and Toxicology, Althansstr. 14, University of Vienna, A-1090, Vienna, Austria 3. Federal Office of Agrobiology, Wieningerstr. 8, A-4020, Linz, Austria |
| Abstract: | Austrian isolates ofFusarium subglutinans andFusarium proliferatum were studied for their ability to produce beauvericin, moniliformin and fumonisin B1 and B2 under laboratory conditions. Analytical methodology for beauvericin was specially adapted for this task. Our analyses showed that the strains produced beauvericin up to 687 mg /kg maize and moniliformin up to 70 mg/kg. The culture ofF. proliferatum in addition produced fumonisin B1 and B2 at levels of 106 and 61 mg/kg,respectively. The preliminary toxicity experiments performed in this study clearly indicated a toxic effect of beauvericin on the contractility of mammalian smooth muscle and thus on mammalian cells. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |