N-acetylglucosaminyltransferase V-deficiency increases susceptibility to murine malaria |
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| Authors: | Akiko Shibui Junko Doi Mohammed E.M. Tolba Chiharu Shiraishi Yoshitaka Sato Shumpei Ishikawa Junichi Watanabe Sadao Nogami Susumu Nakae Sumio Sugano Nobumichi Hozumi |
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| Affiliation: | aDepartment of Medical Genomics, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan;bResearch Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda, Chiba 278-0022, Japan;cDepartment of Veterinary Medicine, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan;dDepartment of Parasitology, Assiut University, Assiut 71515, Egypt;eDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;fFrontier Research Initiative and Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan;gFaculty of Health Sciences, Ryotokuji University, 5-8-1 Akemi, Urayasu, Chiba 279-8567, Japan |
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| Abstract: | It is considered that several glycoproteins on erythrocytes in mammalian species are involved in malaria parasite infection. To elucidate the role of N-glycans on malaria parasite infection, we induced experimental murine malaria infection (using Plasmodium berghei ANKA) in mice deficient in N-acetylglucosaminyltransferase V (Mgat5), which is one of the enzymes involved in β1,6-GlcNAc N-glycan biosynthesis. After infection, Mgat5-/- mice showed severe body weight loss and parasitemia compared with wild-type mice. The Mgat5-/- mice, but not wild-type mice, also showed severe pathology accompanied by marked infiltration of plasma cells into the lungs and liver. These results suggest that β1,6-GlcNAc N-glycans on/in host erythrocytes may interfere with invasion of the parasites and progression to severe malaria. |
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| Keywords: | Mgat5 N-glycosylation Malaria Pathology |
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