Effect of Mexican propolis extracts from Apis mellifera on Candida albicans in vitro growth |
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Authors: | Quintero-Mora María Leonor Londoño-Orozco Amparo Hernández-Hernández Francisca Manzano-Gayosso Patricia López-Martínez Rubén Soto-Zárate Carlos Ignacio Carrillo-Miranda Liborio Penieres-Carrillo Guillermo García-Tovar Carlos Gerardo Cruz-Sánchez Tonatiuh A |
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Institution: | Facultad de Estudios Superiores Cuautitlán, Departamento de Microbiología y Parasitología, Universidad Nacional Autónoma de México, Mexico. marileqm@hotmail.com |
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Abstract: | Propolis is a resinous substance collected by bees (Apis mellifera) from different trees and bushes. Due to its antifungal, antibacterial, antiviral and antiparasitic properties, it has continued to be very popular throughout the time showing variable activity depending on its geographical origin. In Mexico, information about this product is very limited. The aim of this work was to evaluate the antifungal activity of four propolis ethanolic extracts from three different Mexican states, and four commercial extracts on Candida albicans growth. A reference strain (ATCC 10231) and 36 clinical isolates of C. albicans were used. The Minimal Inhibitory Concentration (MIC) was determined by the dilution on agar method. Growth curves on Sabouraud Dextrose broth with and without different propolis ethanolic extracts concentrations were performed. In addition, whether the effect was fungistatic or fungicide was determined. The propolis ethanolic extract obtained from Cuautitlán Izcalli, State of Mexico, showed the best biological activity, inhibiting 94.4% from the clinical isolates at 0.8 mg/ml; the reference strain was inhibited at 0.6 mg/ml. The propolis effect was fungistatic in low concentrations and fungicide in concentrations higher to MIC. The Mexican propolis ethanolic extract could be further investigated for its alternative use for the treatment of some C. albicans infections. |
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