A comparative study of the effects of aflatoxin B1, alpha-amanitin and actinomycin-D on RNA synthesis by rat liver. |
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| Authors: | H R Prasanna S R Gupta L Viswanathan T A Venkitasubramanian |
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| Abstract: | The effect of different combinations of aflatoxin B1, alpha-amanitin and actinomycin-D on the incorporation of orotic acid-6-14C into RNA was investigated using rat liver slices. The results support the view that the mode of action of aflatoxin B1 and alpha-amanitin are similar in some respects, and that aflatoxin B1 and actinomycin-D act according to different mechanisms. Evidence was also obtained about the formation of an active metabolite of aflatoxin B1 in this system. |
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