Linking retroelements to autoimmunity |
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Authors: | Bhoj Vijay G Chen Zhijian J |
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Affiliation: | Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA. |
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Abstract: | In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity. |
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