The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling |
| |
Authors: | Wilson Daniel N Beckmann Roland |
| |
Affiliation: | 1 Gene Center and Department of Biochemistry, Munich (CiPSM), Feodor-Lynenstr. 25, 81377 Munich, Germany;2 Center for Integrated Protein Science, Munich (CiPSM), Feodor-Lynenstr. 25, 81377 Munich, Germany |
| |
Abstract: | As the nascent polypeptide chain is being synthesized, it passes through a tunnel within the large ribosomal subunit and emerges at the solvent side where protein folding occurs. Despite the universality and conservation of dimensions of the ribosomal tunnel, a functional role for the ribosomal tunnel is only beginning to emerge: Rather than a passive conduit for the nascent chain, accumulating evidence indicates that the tunnel plays a more active role. In this article, we discuss recent structural insights into the role of the tunnel environment, and its implications for protein folding, co-translational targeting and translation regulation. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|