Synthesis of new fluorescent nucleoside analogues and application to the study of human deoxycytidine kinase. |
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| Authors: | M Shafiee G Gosselin J L Imbach S Eriksson G Maury |
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| Affiliation: | Laboratoire de Chimie Bioorganique, UMR 5625 du CNRS, Université Montpellier II, France. |
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| Abstract: | We have determined the affinity of human deoxycytidine kinase with respect to new fluorescent N-methylanthraniloyl cytidine derivatives or non fluorescent enantiomeric cytidine analogues. New results regarding the enantioselectivity and the mechanism of the enzyme are presented. |
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