Effect of invariant chain on major histocompatibility complex class I molecule expression and stability on human breast tumor cell lines |
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| Authors: | Xuede Lin Xiaojian Wang Haley L. Capek Laura C. Simone Amit Tuli Chantey R. Morris Adrian J. Reber Joyce C. Solheim |
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| Affiliation: | (1) Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA;(2) Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of China;(3) Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA;(4) Department of Population Health, University of Georgia, Athens, GA, USA |
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| Abstract: | Invariant chain (Ii) binds to the human leukocyte antigen (HLA) class II molecule and assists it in the process of peptide acquisition. In addition, Ii binds to the HLA class I molecule, although there has been little study of its effects on the HLA class I molecule. In addition to its normal expression on antigen-presenting cells, Ii expression is up regulated in a variety of tumors. By flow cytometric analysis, we found that expression of Ii resulted in an increase in the number of cell surface HLA class I molecules and in the proportion of unstable HLA class I molecules at the surface of breast tumor cell lines. These data suggest that the expression of Ii by tumor cells may quantitatively and qualitatively alter the presentation of antigens on those cells. |
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| Keywords: | Antigen presentation Breast cancer Antigens/peptides/epitopes Invariant chain MHC class I molecule |
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