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Histamine-liberating action of MCD-peptide from bee venom] |
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| Authors: | I S Gushchin A I Miroshnikov V I Martynov |
| Abstract: | Histamine release (HR) from the isolated rat mast cells induced by MCD-peptide, mellitin (from the Apis mellifica venom) and compound 48/80 was studied. The dose-response curve, the latent period and temperature dependence of HR induced by MCD-peptide were similar to those of HR induced by compound 48/80. The HR induced by MCD-peptide proved to be an energy-dependent process that was independent of cyclic adenosine-3',5'-monophosphate. |
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