Evolutionary conservation of gene structures of the Pax1/9 gene family |
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Authors: | Hetzer-Egger C Schorpp M Boehm T |
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Affiliation: | Department of Developmental Immunology, Max-Planck-Institute for Immunobiology, Stuebeweg 51, D-79108, Freiburg, Germany. |
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Abstract: | Based on amino acid sequence comparisons, Pax1 and Pax9 genes are considered to form a subgroup of vertebrate Pax genes. We show here that the gene structures of mouse Pax1, human PAX9 genes are similar to that of a single Pax1/9 related gene in Branchiostoma lanceolatum, AmphiPax1. This supports the hypothesis that Pax1 and Pax9 genes were derived from a single ancestral gene. A refined protein alignment of AmphiPax1, mouse Pax1 and human PAX9 proteins based on the determined exon boundaries indicates that sequence divergence at the C-termini may be related to the unique functions of the Pax1 and Pax9 genes in vertebrates. AmphiPax1 is expressed in adult amphioxus in the pharyngeal endoderm. |
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