And the noise played on: stochastic gene expression and HIV-1 infection |
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Authors: | Blake William J Collins James J |
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Affiliation: | Center for BioDynamics and Department of Biomedical Engineering, Boston University, MA 02215, USA. |
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Abstract: | Stochastic gene expression has been implicated in a variety of cellular processes, including cell differentiation and disease. In this issue of Cell, take an integrated computational-experimental approach to study the Tat transactivation feedback loop of HIV-1. They show that fluctuations in a key regulator, Tat, in an isogenic population of infected cells result in two distinct expression states corresponding to latent and productive HIV-1 infection. These findings demonstrate the importance of stochastic gene expression in molecular "decision-making." |
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