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Structural characterization of glycosphingolipids from the eggs of Schistosoma mansoni and Schistosoma japonicum |
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| Authors: | Khoo Kay-Hooi; Chatterjee Delphi; Caulfield John P; Morris Howard R; Dell Anne |
| Institution: | Department of Microbiology, Colorado State University Ft. Collins CO 80523, USA 1Inflammatory Disease Unit Roche Bioscience, Palo Alto, CA 94304, USA 2Department of Biochemistry, Imperial College London SW7 2AY, United Kingdom 4Present address: Institute of Biological Chemistry Academia Sinica, Taipei 115, Taiwan, R.O.C. |
| Abstract: | The granulomatous pathology in human intestinal schistosomiasisis induced primarily by the egg antigens of schistosome, a parasitictrematode. Glycolipids and glycoproteins were extracted fromthe eggs of the two major species which infect human, Schistosomamansoni and Schistosoma japonicum, for structural characterizationbased on highly sensitive mass spectrometric analysis coupledwith chemical derivatization. Here, we demonstrate that a seriesof uniquely multifucosylated glycosphingolipids constitute themajor egg glycolipids of S.mansoni but not of S.japonicum. TheS.mansoni glycosphingolipids were found to be extended by varyingnumbers of an unusual repeating unit, |
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