The Synthesis of Cholesterol-Containing Cationic Amphiphils with Heterocyclic Bases |
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| Authors: | Konstantinova T V Klykov V N Serebrennikova G A |
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| Institution: | (1) Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 117571, Russia |
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| Abstract: | A number of cationic derivatives of cholesterol containing polar residues of N-methylimidazole, pyridine, N-methylmorpholine, and 4-N,N-dimethyaminopyridine were synthesized by the interaction of the corresponding heterocyclic bases with cholesterol 5-bromopentanoate followed by the treatment with methyl iodide in the case of tertiary amines. In addition, N-(4-cholesteryloxycarbonylbutyl)piperazine was obtained for the preparation of pH-sensitive liposomes. |
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| Keywords: | cholesterol cationic derivatives transfection |
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