Comparison of soft tissue calcium levels throughout the life spans of normal and myopathic hamsters |
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| Authors: | M J McBroom J D Welty H Dlouha |
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| Affiliation: | 1. School of Health and Rehabilitation Sciences, Faculty of Health Sciences, Western University, London, Ontario, Canada;2. School of Physical Therapy, Faculty of Health Sciences, Western University, London, Ontario, Canada;3. School of Kinesiology, Faculty of Health Sciences, Western University, London, Ontario, Canada;4. Department of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada;5. Department of Physical Medicine and Rehabilitation, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada;6. Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada |
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| Abstract: | Comparisons of calcium levels in heart, skeletal muscle, brain, liver and plasma were made throughout the life spans of normal and genetically myopathic hamsters. A large calcium accumulation occurred in, and was restricted to, myopathic tissues (heart and skeletal muscle). Calcium elevation in myopathic tissues corresponded to documented lesion appearance, and persisted throughout the remainder of the life span. Calcium buildup in heart and skeletal muscle, as a central feature of the myopathic process, does not reflect a general failure of calcium homeostasis; nonmyopathic tissues are unaffected. Calcium increased moderately in some normal tissues late in life. |
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