L(+)-酒石酸发酵法生产工艺改进的研究

虽然具有广泛用途的Ｌ( ) 酒石酸的生产方法有 4种[1 ] ,但目前研究最多 ,最具工业生产前景的方法 ,是应用化学合成的前体为底物 ,发酵生产Ｌ( ) 酒石酸的方法。该法中的微生物发酵转化适宜在弱碱性的条件下进行 ,通常都是把顺式环氧琥珀酸制备成相应的二钠盐来作为前体 ,再进行微生物转化生成Ｌ( ) 酒石酸。张建国[2 ] 、黄腾华等人[3 ] 在实验室按以上路线生产Ｌ( ) 酒石酸 ;孙志浩等人[4] 以明胶为载体固定化微生物细胞生产Ｌ( ) 酒石酸 ;张建国等人[5 ]在他们自己工作的基础上进一步探讨了细胞固定化的方法 ,找到了一种…

Study on the Improvement of Process Technology ofL( + )-Tartaric Acid Fermentation

This work proposes an improved process technology of L(+)-tartaric acid produced by using cis-epoxysuccinates as the substrate for fermentation. The key to the question is to apply dipotassium cis-epoxysuccinate as the substrate instead of disodium cis-epoxysuccinate. As compared with the original process technology, the improved one has prominent advantages: 1. High yield of acid, increased by 20%-30% over the old one; 2. High rate of recovery, from about 60% to 80%; 3. One of the raw materials is cheaper, the KOH is expensive than NaOH, but half of the K kions could be used cyclically, and the varied products could be obtained easily; 4. The tough working procedure of filtration of fermented liquor could be evaded, the total working procedures might increase to some extent, but the cost of production will be reduced obviously, it is advantageous to industrial production.