DNA疫苗研究进展

DNA疫苗是20世纪90年代初出现的一种新型疫苗，近年来发展迅速，在预防和治疗病毒性疾病及肿瘤等方面效果显著。同传统的疫苗相比，DNA疫苗具有免疫效果好、生产成本低、临床应用方便等优点，但同样存在安全性的担忧。对DNA疫苗的发展及其作用机制、优势进行了综述，并对DNA疫苗的安全性提出了自己的观点与看法，可供DNA疫苗的研究者参考。

Advances in research of DNA vaccine

As a novel vaccine set up in early 1990s, DNA vaccine has been developed rapidly in recent years and played an important role in the prevention and treatment of viral diseases and tumor. Compared with the traditional vaccines, it had some advantages, such as good immune effect, low production cost, and convenient usage for the clinical application, but it could also be found safety concerns. To provide the references for DNA vaccine researchers, the development, mechanism, and advantage are reviewed in this paper, and my personal viewpoint about its safety is presented as well.