A laboratory class experiment to detect and quantify lovastatin in commercial medicaments |
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| Affiliation: | 1. Institute for Integrated Catalysis. Energy and Environmental Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA;2. Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA;3. Department of Chemical & Biomedical Engineering, West Virginia University, Morgantown, WV 26506, USA;1. Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Apdo. Postal 70-360, Cd. Universitaria, México, D.F. 04360, México;2. Posgrado en Ciencia e Ingeniería de Materiales, Universidad Nacional Autónoma de México, Apdo. Postal 70-360, Cd. Universitaria, México, D.F. 04360, México;3. Facultad de Medicina. Universidad Nacional Autónoma de México, Apdo. Postal 70-360, Cd. Universitaria, México 04510, México;4. Instituto Nacional de Rehabilitación, Luis Guillermo Ibarra Ibarra, Av. México Xochimilco 289, Col. Arenal de Guadalupe, Ciudad de México 14389, México;5. Research leave at Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Apdo. Postal 70-360, Cd. Universitaria, México, D.F. 04360, México;1. Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China;2. School of Food and Biological Engineering, Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, Hefei 230009, PR China;1. Laboratory of Functional Materials, College of Physics and Materials Science, Henan Normal University, Henan Key Laboratory of Photovoltaic Materials, Xinxiang 453007, People''s Republic of China;2. Laboratory of Dielectric Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, People''s Republic of China;3. School of Materials Science and Engineering, Guilin University of Electronic Technology, Guilin 541004, People''s Republic of China |
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| Abstract: | This article describes a laboratory class experiment for an undergraduate Biochemistry course for Chemistry students. The experimental work involves the extraction of lovastatin from a medicament utilized in the treatment of hypercholesterolemic patients, and its determination by spectroscopy and by reversed-phase high-performance liquid chromatography. The entire experiment can be performed in one laboratory period, e.g. less than one day. |
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