Membrane redox state and apoptosis: death by peroxide |
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| Authors: | Loscalzo Joseph |
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| Affiliation: | Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Harvard Medical School, Boston, MA 02118-2394, USA. jloscalzo@rics.bwh.harvard.edu |
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| Abstract: | Membrane redox state is governed by the complex interplay between oxidation of unsaturated fatty acids and lipophilic antioxidants. In this issue of Cell Metabolism, Seiler et al. (2008) show that a lipid oxidase, 12/15-lipoxygenase, and a membrane antioxidant enzyme, glutathione peroxidase-4, interact to regulate a novel redox-dependent cell death pathway. |
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