Incorporation of positively charged deoxynucleic S-methylthiourea linkages into oligodeoxyribonucleotides. |
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Authors: | H Challa T C Bruice |
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Institution: | Department of Chemistry and Biochemistry, University of California, Santa Barbara, 93106, USA. |
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Abstract: | Oligodeoxyribonucleic acids (15- and 18-mers) containing both negatively charged phosphate and positively charged S-methyl thiourea internucleoside linkages (DNmt/DNA chimera) have been synthesized. DNA binding characteristics and nuclease resistance of DNmt/DNA chimera have been evaluated. |
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