Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants |
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| Authors: | Yang Yu Agnieszka J Szczepek Heidemarie Haupt Birgit Mazurek |
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| Institution: | 1.Molecular Biology Research Laboratory and Tinnitus Center, Department of Otorhinolaryngology, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117 Berlin, Germany;2.Department of Otorhinolaryngology - Head & Neck Surgery, Tongji Hospital, Huazhong University of Technology & Science, Jiefang Ave. 1095#, 430030 Wuhan, PR China |
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| Abstract: | Background Heat shock protein 70 (HSP70) protects inner ear cells from damage and death induced by e.g. heat or toxins. Benzoquinone
ansamycin antibiotic geldanamycin (GA) was demonstrated to induce the expression of HSP70 in various animal cell types. The
aim of our study was to investigate whether GA induces HSP70 in the organ of Corti (OC), which contains the auditory sensory
cells, and whether GA can protect these cells from toxicity caused by a common aminoglycoside antibiotic gentamicin. |
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