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N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels |
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| Authors: | Bernhard Aigner Birgit Rathkolb Martina Klempt Sibylle Wagner Dian Michel Martin Hrabé de Angelis Eckhard Wolf |
| Institution: | 1. Chair for Molecular Animal Breeding and Biotechnology, Department of Veterinary Sciences, and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich, Germany 2. Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, and Chair for Experimental Genetics, TU Munich, Freising-Weihenstephan, Germany |
| Abstract: | BackgroundClinical chemical blood analysis including plasma electrolytes is routinely carried out for the diagnosis of various organ diseases. Phenotype-driven N-ethyl-N-nitrosourea (ENU) mouse mutagenesis projects used plasma electrolytes as parameters for the generation of novel animal models for human diseases. |
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