Growing functional modules from a seed protein via integration of protein interaction and gene expression data |
| |
Authors: | Ioannis A Maraziotis Konstantina Dimitrakopoulou Anastasios Bezerianos |
| |
Institution: | (1) Department of Medical Physics, School of Medicine, University of Patras, GR26500 Patras, Greece |
| |
Abstract: | Background Nowadays modern biology aims at unravelling the strands of complex biological structures such as the protein-protein interaction
(PPI) networks. A key concept in the organization of PPI networks is the existence of dense subnetworks (functional modules)
in them. In recent approaches clustering algorithms were applied at these networks and the resulting subnetworks were evaluated
by estimating the coverage of well-established protein complexes they contained. However, most of these algorithms elaborate
on an unweighted graph structure which in turn fails to elevate those interactions that would contribute to the construction
of biologically more valid and coherent functional modules. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |