| 核糖体失活蛋白在细胞内的转运途径 |
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| 引用本文： | 王峰 詹金彪. 核糖体失活蛋白在细胞内的转运途径[J]. 细胞生物学杂志, 2005, 27(6): 617-620 |
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| 作者姓名： | 王峰 詹金彪 |
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| 作者单位： | 浙江大学医学院生物化学与分子生物学教研室,杭州310031 |
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| 基金项目： | 国家自然科学基金（No.30270294和No.30070166）和浙江省自然科学基金（No.301057）资助项目 |
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| 摘 要： | 核糖体失活蛋白（ribosome—inactivating proteins，RIPs）是一类抑制蛋白质生物合成的毒蛋白，现已成为研究细胞生物学的重要工具并在临床抗肿瘤和抗病毒治疗上得到了广泛应用。现结合国内外近几年的研究进展就核糖体失活蛋白在细胞内的转运途径作一综述。
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| 关 键 词： | 核糖体失活蛋白 胞内运输 逆向转运 转位 |
| 收稿时间： | 2005-03-21 |
| 修稿时间： | 2005-06-17 |
Transport of Ribosome-inactivating Proteins in the Cell |
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| Feng Wang, Jin-Biao Zhan. Transport of Ribosome-inactivating Proteins in the Cell[J]. Chinese Journal of Cell Biology, 2005, 27(6): 617-620 |
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| Authors: | Feng Wang Jin-Biao Zhan |
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| Affiliation: | Department of Biochemistry and Molecular Biology, Zhejiang University Medical School, Hangzhou 310031, China |
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| Abstract: | Ribosome-inactivating proteins (RIPs) are a group of protein toxins which inhibit protein synthesis in cells. Recently RIPs have been used as molecular probes in cell biology and as anti-cancer and antiviral drugs in clinic. In this review, we focus on the intracellular trafficking and translocation of RIPs based on research recent years. |
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| Keywords: | ribosome-inactivating proteins intracellular trafficking retrograde transport translocation |
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