Metabolism of phenylbenzoate by Pseudomonas sp. strain TR3 |
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| Authors: | Thomas Reicha Stefan Schmidta Peter Fortnagela |
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| Affiliation: | 1. Environmental Engineering Major, Division of Applied Engineering, Dongseo University, Busan 617-716, South Korea;2. Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 609-735, South Korea;1. School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China;2. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China;1. Department of Medicine, Umeå University Hospital; S-901 85 Umeå, Sweden;2. Department of Neuroscience and Locomotion, division of Geriatrics, Linköping University, Linköping, Sweden;3. Astra Arcus, Södertälje, Sweden;4. Department of Medicine, Western General Hospital, Edinburgh, Scotland, UK |
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| Abstract: | A bacterial isolate, tentatively identified as Pseudomonas sp. strain TR3, was found to utilize the diaryl ester phenylbenzoate as sole source of carbon and energy. This strain has the ability to productively degrade phenylbenzoate and some substituted derivatives by a catabolic sequence which was characterized biochemically. The biodegradation of phenylbenzoate is thus initiated by an inducible esterase, effectively hydrolyzing the diaryl esters to produce stoichiometric amounts of two monoaromatic metabolites, identified as benzoate and phenol in the case of phenylbenzoate. The diaryl ester p-tolylbenzoate was hydrolyzed to yield benzoate and 4-methylphenol while 4-chlorophenylbenzoate gave rise to the production of benzoate and 4-chlorophenol. These monoaromatic catabolites were further degraded via the oxoadipate pathway. |
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| Keywords: | Biodegradation Diaryl ester Phenylbenzoate Hydrolysis Ortho pathway Pseudomonas |
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