| 微生物转化制备活性维生素D_3的研究进展 |
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| 引用本文： | 冯海婷,陆凌霄,文鹏,陆群. 微生物转化制备活性维生素D_3的研究进展[J]. 生物技术通报, 2010, 0(4) |
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| 作者姓名： | 冯海婷 陆凌霄 文鹏 陆群 |
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| 作者单位： | 西南交通大学生命科学与工程学院,成都,610031 |
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| 摘 要： | 活性维生素D类药物作为一类高效原料药,采用化学合成方法,制备复杂,限制了其广泛应用。采用微生物转化法条件温和,操作简单,对于活性维生素D3的制备具有重要意义。从甾体羟化菌株,生物转化制备不同活性维生素D3、基因工程在生物转化上的应用及转化率的影响因素等方面综述了其研究进展,并对该领域的发展趋势进行了展望。
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| 关 键 词： | 微生物转化 活性维生素D_3 甾体 放线菌 转化率 |
Advances in Research of Preparing Active Vitamin D_3 by Microbial Transformation |
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| Feng Haiting,Lu Lingxiao,Wen Peng,Lu Qun. Advances in Research of Preparing Active Vitamin D_3 by Microbial Transformation[J]. Biotechnology Bulletin, 2010, 0(4) |
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| Authors: | Feng Haiting Lu Lingxiao Wen Peng Lu Qun |
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| Affiliation: | Feng HaitingLu Lingxiao Wen PengLu Qun(School of Life Science , Engineering of Southwest Jiaotong University,Chengdu 610031) |
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| Abstract: | Active vitamin D is a kind of high performance material medicine. The chemical synthesis of active vitamin D is complex,which has limited the wide application,but preparing active vitamin D3 by microbial transformationin in mild conditions is operated simplely. The paper reviewed the progress of the research from the type of steroid hydroxylation bacteria,biotransformation to different active vitamin D3,genetic engineering applications in the biological transformation and the influencing factors of transfor... |
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| Keywords: | Microbial transformation Active vitamin D_3 Sterides Actinomyces Conversion |
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