THE PROLIFERATIVE STATUS OF INTESTINAL EPITHELIAL CLONOGENIC CELLS: SENSITIVITY TO S PHASE SPECIFIC CYTOTOXI CAGENTS |
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| Authors: | T. A. Boarder N. M. Blackett |
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| Affiliation: | Biophysics Division, Institute of Cancer Research, Sutton, Surrey |
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| Abstract: | High concentrations of tritiated thymidine and cytosine arabinoside (Ara-C) have been used to selectively kill cells in the crypts of Lieberkuhn that are synthesizing DNA. The effect of these agents on the number of regenerating microcolonies seen 3-J days after a range of radiation doses indicates that a majority of the clono-genic cells are proliferating rapidly and that the slowly proliferating cells at the base of the crypt do not represent the whole clonogenic population. |
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