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Natural and synthetic G-quadruplex interactive berberine derivatives |
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| Authors: | Franceschin Marco Rossetti Luigi D'Ambrosio Anna Schirripa Stefano Bianco Armandodoriano Ortaggi Giancarlo Savino Maria Schultes Christoph Neidle Stephen |
| Institution: | Dipartimento di Chimica, Università di Roma La Sapienza, Piazzale A. Moro 5, 00185 Rome, Italy. |
| Abstract: | The interaction of the natural alkaloid berberine with various G-quadruplex DNA structures and its ability to inhibit telomerase have been examined and compared with those of a synthetic piperidino derivative and the related compound coralyne. The results show that these molecules have selectivity for G-quadruplex compared to duplex DNA, and that their aromatic moieties play a dominant role in quadruplex binding. |
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