Selective synthesis and reactions of 6-substituted-2-beta-galactosyl-1,2,4-triazines of potential anticancer activity |
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Authors: | Mansour Abdel Kader Eid Mohga M Khalil Nasser S A M |
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Institution: | Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt. clff@intouch.com |
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Abstract: | Selective synthesis and reactions of different 6-substituted-2-beta-D-galactosyl-3-thioxo-2,3-dihydro-1,2,4-triazin-5(4H)-ones using the developed amino or aryl protecting group strategy were investigated. Primary human anticancer screening of twelve selected compounds (in vitro) resulted in an active compound against both MCF7 (Breast) and SF-268(CNS) cell lines. |
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