Developmental changes in lysosome morphology and function Leishmania parasites |
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| Authors: | Waller Ross F McConville Malcolm J |
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| Affiliation: | Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Vic 3010, Australia. |
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| Abstract: | The endocytic pathway of Leishmania parasites has recently come under intense research focus through the development of several markers for various compartments of this pathway. Through these studies a novel multivesicular tubule lysosome has been discovered in promastigote-stage parasites. This organelle has a highly dynamic role during parasite growth and differentiation. This review discusses recent insights into the Leishmania lysosome with respect to its organisation within the endocytic pathway, stage-specific functions, and biogenesis. |
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| Keywords: | Leishmania Multivesicular tubule lysosome Endocytic pathway Protein trafficking Early endosome Multivesicular bodies Promastigote Amastigote Megasome |
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