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Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors |
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| Authors: | Bosse Todd D Larson Daniel P Wagner Rolf Hutchinson Doug K Rockway Todd W Kati Warren M Liu Yaya Masse Sherie Middleton Tim Mo Hongmei Montgomery Debra Jiang Wen Koev Gennadiy Kempf Dale J Molla Akhter |
| Affiliation: | Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. todd.bosse@abbott.com |
| Abstract: | A series of gem-dialkyl naphthalenone derivatives with varied alkyl substitutions were synthesized and evaluated according to their structure-activity relationship. This investigation led to the discovery of potent inhibitors of the hepatitis C virus at low nanomolar concentrations in both enzymatic and cell-based HCV genotype 1a assays. |
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