Impaired leptin activity in New Zealand Obese mice: model of angiogenesis |
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Authors: | Lukasz Wator Urszula Razny Adriana Balwierz Anna Polus Hans G Joost Grzegorz Dyduch Romana Tomaszewska Aldona Dembinska-Kiec |
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Institution: | 1. Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Cracow, Poland 3. German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany 2. Department of Pathomorphology, Jagiellonian University Medical College, Cracow, Poland
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Abstract: | Leptin is prompt to drive angiogenesis, effecting proper vascularisation. Tissue remodeling (including adipose organ) is associated with the angiogenic response. The aim of this study was to investigate the effect of hyperleptinemia on angiogenesis in subcutaneous (s.c.) in vivo matrigel model in mice on a high fat (HF) diet. HF promoted adipose tissue accumulation and biochemical changes resembling metabolic syndrome. However, the impact of this dietary treatment on angiogenesis, measured in s.c. matrigel model was not significant. Changes in leptin concentration were not accompanied by significant angiogenic response. This lack of leptin activity and impaired signal transduction at the molecular level suggests malfunction of the leptin receptor in NZO mice. |
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