Inhibition of autophagy by benzyl alcohol |
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Authors: | Bjørn Grinde |
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Affiliation: | University of Oslo, Department of Biology, Division of Zoology, P.O. Box 1050, Blindern, N-0316 Oslo 3 Norway |
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Abstract: | Benzyl alcohol caused a rather complete and selective inhibition of the methylamine sensitive (i.e., the putative lysosomal) pathway of protein degradation in isolated rat hepatocytes. The effect was found to be entirely reversible within 30 min of removing the agent. A morphometric examination of electron micrographs revealed that the inhibition of lysosomal protein degradation coincided with a block in the formation of autophagic vacuoles. The number of acidic vacuoles (i.e., vacuoles induced to swell by adding methylamine) was not drastically reduced. |
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Keywords: | Autophagy Protein degradation Benzyl alcohol inhibition (Rat Hepatocyte) |
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