|
|||||
|
|
Studies on two dioxygenases involved in the synthesis of tylosin in Streptomyces fradiae |
|
| Affiliation: | School of Pharmaceutical Sciences, Kitasato University and the Kitasato Institute, 5-9-1, Shirokane, Minato-ku, Tokyo 108 Japan |
| Abstract: | A cell-free extract from the tylosin producer Streptomyces fradiae oxidizes 5-O-mycaminosylprotylonolide to 20-hydroxy-5-O-mycaminosylprotylonolide and 20-oxo-5-O-mycamimosylprotylonolide to 5-O-mycaminosyltylonolide. The enzymes require 2-oxoglutarate and molecular oxygen for full activity. They appear to be 2-oxoglutarate-dependent dioxygenases. |
| Keywords: | Tylosin synthesis 2-Oxoglutarate Dioxygenase Macrolide antibiotic (Streptomyces) MPTL 5-O-mycaminosylprotylonolide PTL protylonolide MTL 5-O-mycaminosyltylonolide |
| 本文献已被 ScienceDirect 等数据库收录！ | |