Circulating proalbumin associated with a variant proteinase inhibitor |
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| Authors: | Stephen O. Brennan Maurice C. Owen D. Ross Boswell Jessica H. Lewis Robin W. Carrell |
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| Affiliation: | 1. Pathology Department, Christchurch Hospital, Christchurch, New Zealand;2. Department of Medicine, University of Pittsburgh, Pittsburgh, PA, U.S.A. |
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| Abstract: | The unique finding of normal proalbumin in human plasma provides an insight into the mechanism of propeptide cleavage. Proalbumin, present as 1–5% of the total albumin, was found in a boy whose prime problem was the presence of a mutant proteinase inhibitor, α1-antitrypsin Pittsburgh (358Met→Arg) [2]. The infeerred structure of human proalbumin was confirmed as Arg | |
| Keywords: | Proteinase inhibitor Proalbumin (Human) |
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