Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth |
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Authors: | Kottis Vicky Thibault Pierre Mikol Daniel Xiao Zhi-Cheng Zhang Rulin Dergham Pauline Braun Peter E |
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Institution: | Department of Biochemistry, McGill University, Montreal, Quebec, Canada. |
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Abstract: | A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested. |
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Keywords: | arretin myelin inhibitors nerve regeneration neurite outgrowth OMgp |
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