Effect of modified low density lipoproteins on humoral immune response and functional activity of macrophages in mice |
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| Authors: | Poveshchenko A F Perminova O M Dushkin M I Kuznetsov P O Vol'skiĭ N N Kozlov V A |
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| Affiliation: | Institute of Clinical Immunology, Institute of Therapy, Siberian Branch, Russian Acad. Med. Sci., Novosibirsk, Russia. |
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| Abstract: | Intravenous injection of acetylated low density lipoproteins (acLDL) in mice in a dose of 0.5 mg per mouse decreased the intensity of humoral immune response to sheep red blood cells (SRBC) by 35%. The addition of acLDL to mouse peritoneal macrophages in vitro resulted in inhibition of Fc-dependent phagocytosis of SRBC and fourfold increased secretion of prostaglandins E2 by macrophages. Fc-dependent phagocytosis of SRBC was also found to be inhibited by oxysterols (25-hydroxycholesterol and 7-ketocholesterol), added to the incubation medium of macrophages in vitro in doses of 0.5-5 mg/ml. The conclusion was made that oxidative metabolism of cholesterol and arachidonic acid, contained in LDL, may mediate the immunomodulating effects of modified LDL. |
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