Plasmodium vinckei: selection of a strain exhibiting stable resistance to arteether |
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| Authors: | Puri S K Chandra Ramesh |
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| Institution: | Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India. |
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| Abstract: | A strain of rodent malaria parasite Plasmodium vinckei showing >12-fold resistance to arteether has been selected after exposure to sub-curative doses of drug in 44 sequential passages over a period of 700 days. Experimentally induced resistance was found to be stable after drug free maintenance of parasites for 11 serial passages over a period of 100 days. Cross-sensitivity studies have shown that apart form resistance to related derivatives like artemether and artesunic acid, the derived parasites also show resistance to quinine and mefloquine. |
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| Keywords: | Malaria Plasmodium vinckei Arteether Drug resistance Artemisinin derivatives |
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