| 离子束诱变粟酒裂殖酵母产辅酶Q_(10)的初步研究 |
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| 引用本文： | 王丽,郑之明,樊永红,苏彩欣,许德军,柳丹,古绍彬,余增亮.离子束诱变粟酒裂殖酵母产辅酶Q_(10)的初步研究[J].激光生物学报,2007(1). |
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| 作者姓名： | 王丽 郑之明 樊永红 苏彩欣 许德军 柳丹 古绍彬 余增亮 |
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| 作者单位： | 中国科学院离子束生物工程学重点实验室 安徽合肥230031 |
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| 基金项目： | 自然科学基金项目(20576132)，中国科学院重要方向性项目(KSCX2-SW-324) |
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| 摘 要： | 辅酶Q10(coenzyme Q10,CoQ)对心脏充血性病人有较好的疗效,是临床常用药物之一。实验研究了离子束诱变粟酒裂殖酵母对提高CoQ10的产量的影响与作用。实验筛选出六株突变菌株,研究了突变株生理生化特性。结果表明:突变菌株的CoQ10产量都有不同程度的提高,其中编号为N1菌株产量达6.9344mg/L,是对照菌株的10倍多,最低的N2菌株的产量也是对照菌株的1.3倍。
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| 关 键 词： | 辅酶Q10 低能离子束 粟酒裂殖酵母 高效液相色谱法 紫外分光光度法 |
A Rudimental Study on Ion Implanting on Schizosaccharomyces promb Producing CoQ_(10) |
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| WANG Li,ZHENG Zhi-ming,FAN Yong-hong,SU Cai-xin,XU De-jun,LIU Dan,GU Shao-bin,YU Zeng-liang.A Rudimental Study on Ion Implanting on Schizosaccharomyces promb Producing CoQ_(10)[J].ACTA Laser Biology Sinica,2007(1). |
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| Authors: | WANG Li ZHENG Zhi-ming FAN Yong-hong SU Cai-xin XU De-jun LIU Dan GU Shao-bin YU Zeng-liang |
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| Institution: | WANG Li,ZHENG Zhi-ming*,FAN Yong-hong,SU Cai-xin,XU De-jun,LIU Dan,GU Shao-bin,YU Zeng-liang* |
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| Abstract: | The mutagenic effects of low energy ion beams on Schizosaccharomyces promb producing coenzyme Q_10 are studied.6 mutants are found for higher CoQ_10 production and their physiological characteristics have been studied, too. The result shows that all of them have an higher production than the ck. Especially, N1 has the highest CoQ_10 production of 6.9344 mg/L. It is 10 times higher than that of the ck. N2 is less higher with an value of 0.6905 mg/L. |
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| Keywords: | coenzyme Q_10 low-energy ion beam Schizosaccharomyces promb high performance liquid chromatog-raphy (HPLC) ultraviolet(UV) |
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