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Structure-activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain |
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| Authors: | Yang Shu-Wei Smotryski Jennifer Matasi Julius Ho Ginny Tulshian Deen Greenlee William J Brusa Rossella Beltramo Massimiliano Cox Kathleen |
| Institution: | a Department of Chemical Research—CV & CNS, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA b Neurobiology Department of Biological Research, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA c Department of Drug Metabolism, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA |
| Abstract: | A series of 2,4-diphenyl-1H-imidazole analogs have been synthesized and displayed potent human CB2 agonist activity. Many of these analogs showed high functional selectivity over human CB1 receptors. The syntheses, structure-activity relationships, and selected pharmacokinetic data of these analogs are described. |
| Keywords: | CB2 Agonist Chronic pain Cannabinoid |
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