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Peptide deformylase inhibitors with non-peptide scaffold: synthesis and structure-activity relationships |
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| Authors: | Lee Seung Kyu Choi Kwang Hyun Lee Sang Jae Lee Jong Sun Park Ji Yun Kim B Moon Lee Bong Jin |
| Affiliation: | a Promeditech Ltd, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea b Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Republic of Korea c Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 599 Gwanak-Ro, Gwanak-Gu, Seoul 151-742, Republic of Korea |
| Abstract: | Peptide deformylase (PDF), which removes the formyl group at the N-terminal methionine residue of nascent protein, has been recognized as a potent target for antibacterial therapy. We report herein the synthesis and structure-activity relationship studies of non-peptide PDF inhibitors. |
| Keywords: | PDF SAR Antibacterial Non-peptide |
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