Decoding BDNF-LTP coupling in cocaine addiction |
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| Authors: | Mao Li-Min Fibuch Eugene E Wang John Q |
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| Institution: | Department of Basic Medical Science, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA. |
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| Abstract: | BDNF is a neurotrophic peptide that regulates synaptic plasticity. New work by Lu and coworkers in this issue of Neuron now identifies BDNF as a gatekeeper of synaptic and behavioral plasticity in cocaine sensitization. In the medial prefrontal cortex, upregulated BDNF facilitates LTP and contributes to neurobehavioral adaptations to psychostimulants. |
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