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A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2 |
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| Authors: | Bu Yanyan Shi Tao Meng Minghui Kong Guiping Tian Yingpu Chen Quancheng Yao Xinsheng Feng Gensheng Chen Haifeng Cheng Haifeng Lu Zhongxian |
| Affiliation: | a Xiamen City Key Laboratory of Metabolism Disease and Metabolic Disease Research Center, Institute for Biomedical Research, Lu Jiaxi Hall, Room 630, Xiamen University, Xiamen, Fujian 361005, China b Nature Product Research Center, Institute for Biomedical Research, Xiamen University, Xiamen, Fujian 361005, China c Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China d Molecular Pathology Graduate Program, University of California San Diego, La Jolla, CA 92093, USA |
| Abstract: | Tyrosine phosphatase Src-homology phosphotyrosyl phosphatase 2 (Shp2) was identified as a potential molecular target for therapeutic treatment of diabetes and obesity. However, there is still no systematic research on the enhancers for the Shp2 enzyme. The present study established a novel powerful model for the high-throughput screening of Shp2 enhancers and successfully identified a new specific Shp2 enhancer, oleanolic acid, from Chinese herbs. |
| Keywords: | Shp2 enhancer Screening system Diabetes Oleanolic acid |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |