Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain |
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| Authors: | Susanne Kruse Sandra Braun Klaus A Deichmann |
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| Affiliation: | (1) University Children's Hospital, University of Freiburg, Mathildenstr. 1, 79106 Freiburg, Germany |
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| Abstract: | Background Although IL-4 and IL-13 share the IL-13 receptor, IL-13 exhibits unique functions. To elicit the cellular basis of these differences, signal transduction processes have been compared. Additionally, the role of the IL-4 receptor alpha (IL-4Rα) variant Q551R was investigated. |
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| Keywords: | asthma IL-4 IL-13 SHP STAT3 |
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