Evolutionary differences between alternative and constitutive protein-coding regions of alternatively spliced genes of Drosophila |
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| Authors: | E. O. Ermakova D. B. Mal’ko M. S. Gelfand |
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| Affiliation: | (1) Lomonosov Moscow State University, Moscow, 199992, Russia;(2) Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, 127994, Russia;(3) State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, 117545, Russia |
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| Abstract: | A total of 790 Drosophila melanogaster genes that are alternatively spliced in a coding region and have orthologs in Drosophila pseudoobscura were studied. It proved that nucleotide substitutions are accumulated in alternative coding regions more rapidly than in constitutive coding regions. Moreover, the evolutionary patterns of alternative regions differing in insertion-deletion mechanisms (use of alternative promoters, splicing sites, or polyadenylation sites) differ significantly. The synonymous substitution rate in coding regions of genes varies more strongly than the nonsynonymous substitution rate. The patterns of substitutions in different classes of alternative regions of Drosophila melanogaster and mammals differ considerably. |
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| Keywords: | molecular evolution alternative splicing Drosophila nucleotide substitutions |
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